Orphan Nuclear Receptors: The Exotics of Xenobiotics
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چکیده
منابع مشابه
Orphan nuclear receptors in drug discovery.
Orphan nuclear receptors provide a unique resource for uncovering novel regulatory systems that impact human health and also provide drug targets for a variety of human diseases. Ligands of nuclear receptors have been used in several important therapeutic areas, such as breast cancers, skin disorders and diabetes. Orphan nuclear receptors, therefore, represent a tremendous opportunity in unders...
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Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lymphocyte development. The orphan nuclear receptor RORgamma has been shown to promo...
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Members of this receptor family are related to each other in terms of their amino acid sequence and their function within cells. They therefore have structural features in common. These include a central highly conserved DNA binding domain and generally greater than 60% homology in the ligand binding domain (LBD). The quintessential characteristic of nuclear receptors, and the basis for the nam...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.r100033200